WebJan 17, 2024 · Introduction Trans sodium crocetinate (TSC) is a synthetic carotenoid with a unique mechanism of action that improves the diffusion of oxygen by reducing oxygen … WebJul 13, 2024 · July 13, 2024. Candidate: Trans sodium crocetinate (TSC) Type: First-in-class small molecule designed to safely re-oxygenate oxygen-deprived tissue, alone or …
Evaluation of Trans-Sodium Crocetinate (TSC) on Peripheral
WebTrans sodium crocetinate (TSC), a synthetic drug containing the carotenoid structure of trans crocetin has been extensively investigated in animal disease models and in human clinical trials. [2] [5] [6] Clinical trials of TSC have focused on testing the compound's effectiveness in sensitizing hypoxic cancer cells to radiation therapy in ... WebFeb 1, 2024 · The results strongly suggested that adding TSC during RT is beneficial for the treatment of GBM and Trans sodium crocetinate offers a novel, easily implemented way to combat hypoxia in tumor tissue. OBJECTIVE A new drug, trans sodium crocetinate (TSC), has been developed to enhance the delivery of oxygen to hypoxic tissues. Cancerous … quest diagnostics silver creek ny
TSC - Diffusion Pharmaceuticals Inc.
WebCrocetin is a natural apocarotenoid dicarboxylic acid that is found in the crocus flower together with its glycoside, crocin, and Gardenia jasminoides fruits. It is also known as … WebTrans-sodium crocetinate provides neuroprotection against cerebral ischemia and reperfusion in obese mice.[Pubmed:25491171] J Neurosci Res. 2015 Apr;93(4):615-22. Trans-sodium crocetinate (TSC) is a novel synthetic carotenoid compound that improves diffusion of small molecules, including oxygen, in solutions. WebTrans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. The current study is the initial investigation of the effects of TSC on oxygen delivery to brain. Adult male rats were intubated and ventilated with 21%, 60%, or 100% oxygen. shipping post office