Witryna20 cze 2024 · In this work, we report the synthesis of novel fluorescent molecules, based on 1,8-naphthalimide thio- and amino-derivatives, designed to display an OFF-ON and ON-OFF photoelectron transfer fluorescence switch upon interaction with a proton-donor drug. We have functionalized the new probes to allow easy formation of a covalent … WitrynaNovel naphthalimide derivatives (NIM) with donor–acceptor architecture were successfully constructed and their unique fluorescent properties were investigated. In particular, the fluorescence intensities of 4-methoxystyrene substituted NIM-1 were solvent independent and its quantum yields varied from 0.4 in toluene to 0.52 in MeOH.
A systematic review on 1,8-naphthalimide derivatives as …
Witryna16 cze 2015 · Fragment-based in silico screening against dynamin I (dynI) GTPase activity identified the 1,8-naphthalimide framework as a potential scaffold for the design of new inhibitors targeting the GTP binding pocket of dynI. Structure-based design, synthesis and subsequent optimization resulted in the development of a library of 1,8 … Witryna1 lut 2013 · Linking these active naphthalimide derivatives with other active pharmacophore has become an interesting area of research. The utility of naphthalimide derivatives as novel pharmaceutical and photochemical agents can be further enhanced by introducing polar side chains and fusing functionalized heterocyclic rings with … eyota high school
Spectroscopic properties of 1,8-naphthalimides derivatives: the
Witryna4 paź 2024 · A set of 1,8-naphthalimide (NPI)-substituted 4,4-difluoroboradiaza-s-indacene (BODIPY) dyads 1 a-1 c were designed and synthesized by the Pd-catalyzed Sonogashira cross-coupling reaction of ethynyl substituted NPI 1 with the meso-, β-, and α-halogenated BODIPYs a, b, and c, respectively. The BODIPY … Witryna27 sie 2024 · Thus, many new naphthalimide derivatives have been developed as anticancer agents. 9, 10 We previously synthesized several naphthalimide derivatives and found them to exhibit cytotoxic effects on B16F10 melanoma cells and reduce lung metastasis at least partly through the inhibition of topo II activity. 15, 16 Among the … WitrynaLinking these active naphthalimide derivatives with other active pharmacophore has become an interesting area of research. The utility of naphthalimide derivatives as novel pharmaceutical and photochemical agents can be further enhanced by introducing polar side chains and fusing functionalized heterocyclic rings with naphthalimide cores. does cbd oil help with menstrual cramps