2024 Phenolic phthiocerol

Phenolic phthiocerol

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August undefined, 2024

WebChEBI Name phenolic glycolipid-1: ChEBI ID CHEBI:59104: Definition A lipooligosaccharide whose structure comprises a phenolic phthiocerol core linked to a unique trisaccharide (3,6-di-O-methyl-α-D-glucopyranosyl-(1→4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1→2)-3-O-methyl-α-L-rhamnopyranose) at one end and a mixture of long-chain mycocerosyl fatty … WebDec 25, 1982 · Preparation of DeacylatedPhen GL-I, Fatty Acids, a n d the Phenolic Phthiocerol Core-The procedures were based on those of Demarteau-Ginsburg and Lederer (12), and Gastambide-Odier and Sarda (13). Phen GL-I was hydrolyzed with 10% NaOH in benzene/ methanol (12; 1.5 ml) in a sealed tube under Nz at 100 "C for 18 h.

Mycobacterium tuberculosis enters macrophages with aid from a ... - PNAS

Webphenolic: (fĭ-nō′lĭk, -nŏl′ĭk) adj. Of, relating to, containing, or derived from phenol. n. Any of various synthetic thermosetting resins, obtained by the reaction of phenols with simple … WebOct 19, 2024 · A phenol injection helps limit the signals sent from your nerves to your muscles that cause contractions. This allows you to move more easily and feel less … in the best case synonym

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WebOct 1, 2014 · TLDR This review will focus on phthiocerol dimycocerosates (PDIMs), a long-known and well-studied group of complex lipids found in the M. tuberculosis cell envelope that have an involvement in bacterial virulence, in association with the ESX-1 secretion system. 9 Mycobacterium tuberculosis metabolism. D. Warner Biology, Medicine WebApr 30, 2014 · Peripheral blood monocytes were pretreated with phenolic glycolipid-I (PGL-I), dimycocerosyl phthiocerol (DIM), or mycoside A, then cultured in the presence or absence of interferon-gamma (IFN-gamma). WebDec 9, 2014 · Here, we will address exclusively the proposed role for phthiocerol dimycocerosates (DIM) in the modulation of the resident macrophage response and that of phenolic glycolipids (PGL) in the regulation of the recruitment and phenotype of incoming macrophage precursors to the site of infection. new homes in 85338

Characterization of phthiocerol and phthiodiolone ... - Europe PMC

Phenolic phthiocerol C37H68O4 - PubChem

WebThese enzymes are involved in the biosynthesis of phthiocerol dimycocerosates (DIMs) and the related phenolic glycolipids (PGLs), major lipid virulence factors [49] [50] [51]. Mas... WebThe phenolic phthiocerol core of Phen GL-I was permethyl- ated in similar fashion, except that the reaction mixture was extracted with hexane, and final purification by preparative TLC was accom- plished with ether/hexane (8:2). Analytical and Other Chemical Procedures-TLC was conducted on commercial Silica Gel G plates (Rediplates, Fischer ... new homes in 55+ communitiesWebSurface-exposed unusual lipids containing phthiocerol and phenolphthiocerol are found only in the cell wall of slow-growing pathogenic mycobacteria and are thought to play important roles in host-pathogen interaction. The enzymology and molecular genetics of biosynthesis of phthiocerol and phenolphthiocerol are unknown. We postulate the domain organization … new homes in 55901

"WebDistribution of Phthiocerol Diester, Phenolic Mycosides and Related Compounds in Mycobacteria Microbiology Society Volume 134, Issue 7 Research Article Free … " - Phenolic phthiocerol

Phenolic phthiocerol

Characterization of phthiocerol dimycocerosates from

WebDec 23, 2011 · In addition, the MS/MS spectrum showed fragment ion peaks m/z 1371 based on the elimination of methyl deoxysugar, m/z 1135 and 1093 based on the elimination of the C26:0 and C29:0 FAs, m/z 696 based on the elimination of both C26:0 and C29:0 FAs, and m/z 535 for the phenolic phthiocerol that lacked methyl deoxysugar and C26:0 and C29:0 … WebAcid hydrolysis of deacylated Phenolic glycolipid-I yielded a phenolic phthiocerol "core," and mass spectrometry and proton NMR of the permethylated core suggested the following structure: (formula, see text) Combined gas-liquid chromatography-mass spectrometry showed three tetramethyl branched "mycocerosic" acids, C30, C32 and C34, with …

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WebNational Center for Biotechnology Information WebJul 1, 1983 · PGLs are considered a glycosylated form of phthiocerol dimycocerosates (PDIM) (126). These glycolipids have been mainly studied in Mycobacterium leprae (triglycosylated PGL-I) (127) (128) (129)...

WebThere is now a considerable body of evidence to suggest that the phthiocerol-containing lipids, including the phenolic glycolipids, comprise the so-called “peribacillary substance”, … WebNov 16, 2015 · The phthiocerol family consists of phthiocerol A, phthiocerol B, phthiodiolone A, and phthiotriol A, of which phthiocerol A and phthiodiolone A are the most commonly present. In M. marinum , a major analogous PGL family consisting of the long-chain β-diol backbone modified with a phenolic group at the terminal, to which a 3- O …

WebJun 4, 2024 · In addition, the most significant elevations of metabolite molecules of triglyceride, sphingomyelin, phosphorylcholine, ceramides, phenolic phthiocerol, as well as topped reductions of phosphoethanolamines, diradylglycerols, 1α,25‐dihydroxy‐24‐oxo‐22‐oxavitamin D3, 2‐deoxy‐20‐hydroxy‐5alpha‐ecdysone … WebPhthiocerol. Aside from the PDIMs and related molecules, PKS-derived moieties are present in SL-1 (as hydroxyphthioceranic acid), DATs, and triacyl trehaloses (TATs). From: …

WebJun 26, 2024 · It consists of a lipid phthiocerol dimycoserosate and a phenolic glycolipid. This glycolipid is made up of three methylated sugars linked by phenol to phthiocerol (fat), known as phenolic glycolipid or PGL; it is chemically unique and the trisaccharide is referred to as specific to M. leprae.

Webphenolic phthiocerol. Molecular Formula C 37 H 68 O 4; Average mass 576.933 Da; Monoisotopic mass 576.511780 Da; ChemSpider ID 26331526 new homes in 85383WebAccording, a diacylphenolicphthiocerol was ruled out. The putative diacylphthiocerol (24 mg) was dissolved in 500 pl of benzene and refluxed with 1 ml of 15% KOH in methanol. … new homes in 89031WebApr 9, 2024 · The basal methoxylated diols, phthiocerol A, and phthiocerol B (Minnikin and Polgar 1965, 1966b; Maskens et al. 1966) are usually accompanied by a ketone, … new homes in 89183WebOct 11, 1983 · Mycocerosic acids are diesterified to the phthiocerols, with the resultant phthiocerol dimycocerosate being over 100 carbons in size and highly resistant to hydrolysis.45 Additionally, mycocerosic acids are present as the lipid moiety in phenolic glycolipids (PGLs) found in M. bovis and unusual “Canetti” variants of M. … new homes in 78254WebJul 8, 2015 · M. kansasii and “M. canettii” have characteristic lipooligosaccharides, associated with motility and biofilms, and glycosyl phenolphthiocerol dimycocerosates (“phenolic glycolipids”). Both these... in the best-case quicksort isWebPhthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) contribute to the pathogenicity of several mycobacteria. Biosynthesis of these virulence factors requires … new homes in 89178WebtesA. Probable thioesterase tesa; Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to the outer cell wall layer of M.tuberculosis and are important virulence factors . In vitro, TesA has both thioesterase and esterase activities . new homes in 92081