WebDec 13, 2024 · Mutations in PTPRD have been associated with the development of several brain disorders such as intellectual disabilities, ASD, ADHD, OCD, schizophrenia, RLS, AD, … WebJun 1, 2009 · Here, we show that the receptor protein tyrosine phosphatase delta (PTPRD) is frequently inactivated in glioblastoma multiforme (GBM), a deadly primary neoplasm of the brain. PTPRD is a target of ...
UniProt
WebThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two … WebFeb 2, 2024 · PTPRD is expressed highly in the brain compared to non-brain tissues, especially in myelinating axons and growth cones 33,34 in the prenatal cerebellum 35. sani cloth 70 wipes
Genome-wide association study of pediatric obsessive ... - Nature
WebJan 1, 2009 · The PTPRD gene is composed of 36 coding sequence exons and a 5 UTR spliced together from 11 non-coding exons. ... In addition, the brain isoform is characterized by the absence of exons 14 to 18 corresponding to amino acid residues 568 to 978 of the 4 th through 7 th fibronectin III-like domain and by the insertion of a 12 base pair mini-exon ... WebDec 15, 2008 · An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor … WebJul 14, 2015 · The receptor type protein tyrosine phosphatase D (PTPRD) gene encodes a cell adhesion molecule likely to influence development and connections of addiction-, … sani cloth active karta charakterystyki